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Article Dans Une Revue Advanced Materials Année : 2024

Strategies for the Nuclear Delivery of Metal Complexes to Cancer Cells

Résumé

AbstractThe nucleus is an essential organelle for the function of cells. It holds most of the genetic material and plays a crucial role in the regulation of cell growth and proliferation. Since many antitumoral therapies target nucleic acids to induce cell death, tumor‐specific nuclear drug delivery could potentiate therapeutic effects and prevent potential off‐target side effects on healthy tissue. Due to their great structural variety, good biocompatibility and unique physico‐chemical properties, organometallic complexes and other metal‐based compounds have sparked great interest as promising anticancer agents. In this review, strategies for specific nuclear delivery of metal complexes are summarized and discussed to highlight crucial parameters to consider for the design of new metal complexes as anticancer drug candidates. Moreover, the existing opportunities and challenges of tumor‐specific, nucleus‐targeting metal complexes are emphasized to outline some new perspectives and help in the design of new cancer treatments.This article is protected by copyright. All rights reserved

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Cancer
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https://cnrs.hal.science/hal-04379052

Soumis le : mercredi 17 janvier 2024-14:08:39

Dernière modification le : vendredi 19 avril 2024-16:18:58

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hal-04379052 , version 1 (17-01-2024)

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Marie Huynh, Robin Vinck, Benjamin Gibert, Gilles Gasser. Strategies for the Nuclear Delivery of Metal Complexes to Cancer Cells. Advanced Materials, 2024, ⟨10.1002/adma.202311437⟩. ⟨hal-04379052⟩

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